Biometrics. 2026 Jan 6;82(1):ujag003. doi: 10.1093/biomtc/ujag003.

ABSTRACT

Synthesizing information from multiple data sources is crucial for constructing accurate individualized treatment rules (ITRs). However, privacy concerns often present significant barriers to the integrative analysis of such multicenter data. Classical meta-learning, which averages local estimates to derive the final ITR, is frequently suboptimal due to biases in these local estimates. To address these challenges, we propose a convolution-smoothed weighted support vector machine for learning the optimal ITR. The accompanying loss function is both convex and smooth, which allows us to develop an efficient multiround distributed learning procedure. Such distributed learning ensures optimal statistical performance with a fixed number of communication rounds, thereby minimizing coordination costs across data centers while preserving data privacy. Our method avoids pooling subject-level raw data and instead requires only sharing summary statistics. Additionally, we develop an efficient coordinate gradient descent algorithm, which guarantees at least linear convergence for the resulting optimization problem. Extensive simulations and an application to sepsis treatment across multiple intensive care units validate the effectiveness of the proposed method.

PMID:41642619 | DOI:10.1093/biomtc/ujag003