Electroacupuncture combined with nutritional intervention for gastrointestinal cancer-related sarcopenia: a randomized controlled trial using ultrasonographic indices
Support Care Cancer. 2026 Feb 14;34(3):203. doi: 10.1007/s00520-026-10436-0. ABSTRACT OBJECTIVE: This randomized controlled trial aimed to evaluate the efficacy of electroacupuncture combined with nutritional intervention for cancer-related sarcopenia compared to nutritional intervention alone. Muscle thickness and elasticity were assessed using ultrasonography to calculate relevant parameters. By integrating these objective measures with conventional indicators and scales, […]
Recent from Clinical Trials
Bioclear vs. Conventional Matrices for the Management of Anterior Black Triangles
J Coll Physicians Surg Pak. 2026 Feb;36(2):199-203. doi: 10.29271/jcpsp.2026.02.199. ABSTRACT OBJECTIVE: To compare 6-month periodontal outcomes and restoration quality between Bioclear and conventional resin restorations in the management of anterior black triangles. STUDY DESIGN: Randomised controlled trial. Place and Duration of the Study: Department of Periodontology, Hefei Stomatological Hospital, Hefei Stomatology Clinical College, Anhui Medical […]
Predicting effect and evaluating cost-effectiveness of a family intervention after acquired brain or spinal cord injury: a randomized controlled trial
J Rehabil Med. 2026 Feb 11;58:jrm44691. doi: 10.2340/jrm.v58.44691. ABSTRACT OBJECTIVE: To predict treatment response of a family intervention and investigate its cost-effectiveness from a healthcare payer perspective. DESIGN: Explorative predictor analyses and trial-based economic evaluation. SUBJECTS/PATIENTS: Participants (n=157) were enrolled 4 months to 2 years after discharge from a specialized neurorehabilitation unit. METHODS: Injury type, […]
Effects of high-intensity interval training on depressive symptoms in Hong Kong community-dwelling older adults with mild to moderate depressive symptoms: a study protocol for a cluster randomized controlled trial
Front Public Health. 2026 Jan 27;14:1697763. doi: 10.3389/fpubh.2026.1697763. eCollection 2026. ABSTRACT BACKGROUND: Older adults with mild to moderate depressive symptoms are at high risk of developing severe depression along with complications, disability, and mortality. Early intervention during mild to moderate stages of depressive symptoms is important to prevent further deterioration. Exercise as a readily available […]
Strength Training Versus Walking on the Fibromyalgia Impact: A Blinded Randomised Controlled Trial
Musculoskeletal Care. 2025 Dec;23(4):e70186. doi: 10.1002/msc.70186. ABSTRACT OBJECTIVE: To compare the effect of 24 sessions of progressive intensity strength training on the impact of fibromyalgia (primary outcome). Furthermore, we evaluated its effects on sleep, anxiety, depression, wind-up mechanism, conditioned pain modulation, cutaneous sensory threshold, musculoskeletal performance, walking ability, perceived improvement, and treatment adherence (secondary outcomes). […]
A protocol for an emergency front-of-neck airway registry in the United Kingdom
BJA Open. 2026 Feb 3;17:100526. doi: 10.1016/j.bjao.2025.100526. eCollection 2026 Mar. ABSTRACT BACKGROUND: A ‘cannot intubate, cannot oxygenate’ crisis is a rare but life-threatening airway emergency, with an emergency front-of-neck airway (eFONA) required to establish or maintain oxygenation. Episodes of eFONA are rare, with the UK-wide Fourth National Audit Project from the Royal College of Anaesthetists […]
FPSIR predicts clinical therapeutic responses and survival outcomes in patients with metastatic colorectal cancer undergoing first-line bevacizumab-containing chemotherapy
Front Immunol. 2026 Jan 27;17:1683928. doi: 10.3389/fimmu.2026.1683928. eCollection 2026. ABSTRACT BACKGROUND: Identifying patients who are most likely to benefit from the combination of bevacizumab and chemotherapy (Bev/CT) is essential for the optimal management of metastatic colorectal cancer (mCRC). The aim of this study is to investigate the utility of chronic inflammatory biomarkers in predicting clinical […]
The clinical and cost-effectiveness of paravertebral blockade versus thoracic epidural blockade in reducing chronic post-thoracotomy pain: TOPIC2 RCT synopsis
Health Technol Assess. 2026 Feb;30(16):1-21. doi: 10.3310/GJFG1715. ABSTRACT BACKGROUND: More than a third of patients undergoing thoracotomy suffer from debilitating chronic post-thoracotomy pain lasting months or years postoperatively. Aggressive management of acute pain during the perioperative period may mitigate this risk. OBJECTIVE(S): To determine the clinical and cost-effectiveness of paravertebral blockade compared to thoracic epidural […]
Vascular Comorbidities and an Increased Comorbidity Score Are Associated With Disability and Disability Progression in Secondary Progressive Multiple Sclerosis
Eur J Neurol. 2026 Feb;33(2):e70517. doi: 10.1111/ene.70517. ABSTRACT BACKGROUND: Vascular risk factors are associated with increased disease activity and disability progression in multiple sclerosis (MS). This has been studied mainly in cohorts with relapsing-remitting MS. However, the association between vascular comorbidities (VCM) and clinical disability in secondary progressive MS (SPMS) is less well studied. Our […]
Reductions in cigarette and cannabis use during a randomized clinical trial for alcohol use disorder
Alcohol Alcohol. 2026 Jan 14;61(2):agag006. doi: 10.1093/alcalc/agag006. ABSTRACT OBJECTIVES: Alcohol, tobacco, and cannabis are the most frequently used psychoactive substances in the United States and are commonly used concurrently. This study analyzed patterns of cigarette and cannabis use during a randomized controlled trial (RCT) for alcohol use disorder (AUD). METHODS: This secondary analysis of a […]
Conservative versus liberal oxygenation targets in critically ill children: the Oxy-PICU RCT
Health Technol Assess. 2026 Feb;30(13):1-20. doi: 10.3310/HHYY5898. ABSTRACT BACKGROUND: The optimal target for systemic oxygenation in critically ill children is unknown. Liberal oxygenation is widely practised but is associated with harm in observational studies. OBJECTIVES: To evaluate the clinical and cost-effectiveness of a conservative oxygenation target of peripheral oxygen saturation 88-92% compared with peripheral oxygen […]
Comparison of Five Osteotomy Protocols on Implant Stability and Postoperative Anxiety: A Randomized Controlled Trial
Clin Implant Dent Relat Res. 2026 Feb;28(1):e70125. doi: 10.1111/cid.70125. ABSTRACT PURPOSE: This randomized controlled clinical trial compared five implant osteotomy techniques-high-speed drilling (800 rpm), moderate-speed drilling (300 rpm), ultra-low-speed drilling (50 rpm), osseodensification, and bone condensation-with respect to insertion torque (IT), early implant stability quotient (ISQ) progression, and immediate postoperative VAS-anxiety during early osseointegration. MATERIALS […]
Exploring heterogeneity in treatment effects: The impact and interaction of asset-based wealth and mass azithromycin distribution on child mortality
PLoS One. 2026 Feb 9;21(2):e0341665. doi: 10.1371/journal.pone.0341665. eCollection 2026. ABSTRACT OBJECTIVE: To examine how child mortality among children aged 1-59 months varies by asset-based wealth status in rural Burkina Faso, and to assess the interaction between mass azithromycin (AZ) distribution and wealth status on child mortality at both the household and community levels. METHODS: We […]
Repurposing Oxfendazole for Onchocerciasis: Population Pharmacokinetics of a Tablet Formulation in Healthy African Adults
CPT Pharmacometrics Syst Pharmacol. 2026 Feb;15(2):e70189. doi: 10.1002/psp4.70189. ABSTRACT Global efforts to eliminate onchocerciasis are hampered by the lack of a macrofilaricidal drug capable of killing adult parasites. Oxfendazole, a veterinary anthelminthic, exhibits macrofilaricidal activity and holds promise to shorten treatment durations. Phase 1 studies in healthy Caucasian adults demonstrated favorable pharmacokinetics and safety using […]
Protocol of a multi-centre randomized controlled trial to compare pericapsular nerve group block, fascia-iliaca compartment block and femoral nerve block for pain management in patients with a hip fracture in the emergency department (CPFF-ED)
PLoS One. 2026 Feb 9;21(2):e0342422. doi: 10.1371/journal.pone.0342422. eCollection 2026. ABSTRACT BACKGROUND: Patients presenting in the emergency department (ED) with a hip fracture are often in significant pain. Opioids are frequently prescribed as part of standardized pain protocols, but are associated with many adverse events, especially in the elderly. Regional anaesthesia with a femoral nerve block […]
Effect of high time under tension strength training on different muscular actions in the performance of runners: A randomized controlled trial
PLoS One. 2026 Feb 9;21(2):e0342428. doi: 10.1371/journal.pone.0342428. eCollection 2026. ABSTRACT BACKGROUND: Strength training (ST) for runners is typically based on low volumes and high intensities. However, alternative approaches emphasizing higher volume and lower intensity, such as protocols with high time under tension (TUT), remain underexplored in this population. Notably, the effects of high-TUT may vary […]
Telerehabilitation transforms recovery: Elevating outcomes for lower limb amputees
Prosthet Orthot Int. 2026 Feb 1;50(1):8-14. doi: 10.1097/PXR.0000000000000440. Epub 2025 Apr 8. ABSTRACT BACKGROUND: Telerehabilitation provides a viable alternative for individuals facing barriers to in-person rehabilitation because of transportation issues and physical limitations. It enables remote monitoring and guidance, allowing patients to continue rehabilitation at home. OBJECTIVE: This study aimed to assess the effectiveness of […]
Safety and Preliminary Clinical Effects of a Herbal Balance Solution in Mild-To-Moderate Acne Vulgaris: An Open-Label, Single-Arm Pilot Study
J Cosmet Dermatol. 2026 Feb;25(2):e70702. doi: 10.1111/jocd.70702. ABSTRACT OBJECTIVE: Acne is a common skin condition that seriously affects the physical and mental health of patients. In addition to the standard acne treatment, anti-acne skin care products are gradually becoming essential in preventing and treating acne. Herbal Balance Solution contains multiple botanical ingredients with potential anti-inflammatory […]
Enhancing Delivery of High-Quality Communication at Discharge: A Pilot Study of Presence Circles With Nursing Students
Nurs Health Sci. 2026 Mar;28(1):e70300. doi: 10.1111/nhs.70300. ABSTRACT Nurse-caregiver communication at discharge is critical to ongoing care of the patient but is often hindered by system-level barriers. Meaningful interpersonal encounters, or presence, are known to enhance clinical interactions amidst system-level demands. Nursing students (16) were randomly assigned to an intervention or control arm of the […]
The Safety and Efficacy of a Novel Saw Palmetto (Serenoa repens) Extract for Promoting Hair Growth in Adults With Self-Perceived Thinning Hair: 180-Day Results
J Cosmet Dermatol. 2026 Feb;25(2):e70717. doi: 10.1111/jocd.70717. ABSTRACT BACKGROUND: Hair loss remains a global concern for both men and women. AIMS: This study assessed the efficacy and safety of a proprietary extract of bioactive fatty acids from saw palmetto (Serenoa repens) for treating self-perceived thinning hair in healthy adult men and women (SEREVELLE, Valensa International; […]
Consumer preferences for alternative eco-packaging: A field experiment on wine
Food Res Int. 2026 Mar 1;227:118287. doi: 10.1016/j.foodres.2025.118287. Epub 2025 Dec 29. ABSTRACT Food packaging is rapidly evolving, constantly urged by environmental protection pressures and new consumer needs. However, the wine sector is generally extremely conservative, particularly in traditional producing countries such as Italy. To investigate consumer responses to sustainable packaging innovations, such as wine […]
Generalizability of Edaravone Efficacy
Muscle Nerve. 2026 Feb;73 Suppl 1(Suppl 1):S16-S18. doi: 10.1002/mus.70042. ABSTRACT The pivotal phase 3 trial MCI186-19 (Study 19) demonstrated the efficacy of intravenous edaravone in slowing functional decline in patients with amyotrophic lateral sclerosis (ALS), leading to United States Food and Drug Administration approval. Study 19 utilized a targeted enrollment enrichment strategy based on post […]
Bioequivalence and Pharmacokinetic Evaluation of Gliclazide Modified-Release Tablets in Healthy Chinese Volunteers
Clin Pharmacol Drug Dev. 2026 Feb;15(2):e70021. doi: 10.1002/cpdd.70021. ABSTRACT This was a single-center, randomized, open-label, two-formulation, and two-cycle crossover trial conducted in 52 healthy Chinese volunteers, under fasting and fed conditions. The participants received oral doses of the test formulation (gliclazide modified-release tablets) and reference formulation (30 mg) during each study period. Blood samples were […]
Effects of Siltuximab Versus Corticosteroids in Preventing COVID-19 Pneumonia Disease Progression: Multicentre, Open-Label, Randomized Clinical Trial
Clin Transl Sci. 2026 Feb;19(2):e70491. doi: 10.1111/cts.70491. ABSTRACT In 2020, COVID-19 caused a global health crisis, prompting research efforts and accelerating drug development. As part of this response, we conducted a phase 2b, multicentre, open-label, randomized (1:1) clinical trial to compare the effects of siltuximab versus corticosteroids on disease progression in hospitalized adults with COVID-19 […]
Efficacy and Safety of Clascoterone Cream 1% for Acne Are Independent of Age and Sex
J Drugs Dermatol. 2026 Feb 1;25(2):119-124. doi: 10.36849/JDD.9388. ABSTRACT Acne vulgaris is an inflammatory skin condition affecting adolescents and adults of both sexes. Clascoterone cream 1% is indicated for the topical treatment of acne vulgaris in patients ≥12 years of age based on the results of two Phase 3 trials (NCT02608450 and NCT02608476). This post […]
A comparative pharmacokinetic evaluation of two aqueous progesterone 25 mg injections in healthy postmenopausal women under fasting conditions: An open-label, balanced, randomized, two-treatment, two-period, two-sequence, single-dose, crossover bioequivalence study
Clin Pharmacol Drug Dev. 2026 Feb;15(2):e70025. doi: 10.1002/cpdd.70025. ABSTRACT The growing demand for assisted reproductive technology (ART) has increased the need for effective luteal phase support. Progesterone, essential for maintaining early pregnancy, is a critical component of ART. This open-label, balanced, randomized, two-treatment, crossover, single-dose study compared the bioequivalence of aqueous progesterone 25 mg injection […]
Cognitive intervention based on Positive Emotion-Engagement Relationship-Meaning-Achievement theory in patients with depression and insomnia: Application value
World J Psychiatry. 2026 Feb 19;16(2):110880. doi: 10.5498/wjp.v16.i2.110880. eCollection 2026 Feb 19. ABSTRACT BACKGROUND: Depression and insomnia are highly prevalent mental disorders with a significant comorbidity rate, each exacerbating the severity and course of the other in a bidirectional relationship. Current clinical interventions, including pharmacotherapy and traditional cognitive-behavioral therapy, primarily focus on alleviating negative symptoms […]
The influence of stigma on PrEP uptake among adolescent girls and young women in Johannesburg, South Africa and Mwanza, Tanzania: Qualitative findings from the EMPOWER study
PLoS One. 2026 Feb 3;21(2):e0339380. doi: 10.1371/journal.pone.0339380. eCollection 2026. ABSTRACT BACKGROUND: Adolescent girls and young women (AGYW) in sub-Saharan Africa need HIV prevention options. Stigma may impede uptake and consistent use of oral pre-exposure prophylaxis (PrEP). We sought to understand how stigma manifested and influenced decisions of AGYW participating in a PrEP demonstration trial in […]
Atraumatic Versus Silver-Modified Atraumatic Restorative Treatment in Primary Molars: A Randomized Clinical Trial on Minimally Invasive Caries Management and Oral Health-Related Quality of Life
Clin Exp Dent Res. 2026 Feb;12(1):e70299. doi: 10.1002/cre2.70299. ABSTRACT OBJECTIVES: To compare the 6-month clinical success of atraumatic restorative treatment (ART) and silver-modified atraumatic restorative treatment (SMART) in primary molars of children with early childhood caries (ECC), and to assess the impact of these treatments on oral health-related quality of life (OHRQoL). MATERIALS AND METHODS: […]
SNF-CLIMEDIN: A Randomized Trial of Digital Support and Intervention in Patients With Advanced Non-Small Cell Lung Cancer. A Hellenic Cooperative Oncology Group Study
JCO Clin Cancer Inform. 2026 Feb;10:e2500234. doi: 10.1200/CCI-25-00234. Epub 2026 Feb 3. ABSTRACT PURPOSE: This trial aims to investigate the effectiveness of online digital intervention in patients with non-small cell lung cancer (NSCLC) in terms of adverse events (AEs) and quality of life (QoL). METHODS: This randomized trial recruited 200 patients with advanced NSCLC (March […]
Body-worn cameras to prevent workplace aggression among ticket inspectors: Protocol for a randomized controlled trial
PLoS One. 2026 Feb 3;21(2):e0342270. doi: 10.1371/journal.pone.0342270. eCollection 2026. ABSTRACT BACKGROUND: Service and frontline personnel are among the occupational groups with the highest rates of workplace aggression. To address the risk of victimization, various preventive measures have been introduced, with body-worn cameras increasingly adopted. However, evidence of their effectiveness remains inconclusive, with existing studies heavily […]
The Effects of Sodium Dichloroisocyanurate and Calcium Hydroxide as Intracanal Medicaments on Microhardness and Fracture Resistance of Dentin: An In Vitro Study
Clin Exp Dent Res. 2026 Feb;12(1):e70294. doi: 10.1002/cre2.70294. ABSTRACT OBJECTIVES: The aim of this study was to evaluate the effect of sodium dicholoroisocyanurate (NaDCC) as intracanal medicament on the dentin microhardness and fracture resistance of teeth compared to calcium hydroxide (CH). MATERIAL AND METHODS: Root canals of mandibular premolars (n = 153) were instrumented and […]
Phase 1/2 randomized, observer-blind clinical trial of a first-generation, mRNA-based vaccine against seasonal influenza and COVID-19 in healthy adults
Hum Vaccin Immunother. 2026 Dec;22(1):2589644. doi: 10.1080/21645515.2025.2589644. Epub 2026 Feb 2. ABSTRACT A multicomponent vaccine against seasonal influenza and COVID-19 could reduce disease burden in adults by providing simultaneous protection in a single-dose regimen. The first-generation, mRNA-based, multicomponent mRNA-1073 vaccine, combining antigens encoded by mRNA-1010 (influenza) and mRNA-1273 (COVID-19) vaccines, was investigated in a phase […]
Sustained impact of motivational interviewing on reducing vaccine hesitancy among postpartum mothers: A randomized control trial, Southeastern France, 2021 to 2022
Hum Vaccin Immunother. 2026 Dec;22(1):2611647. doi: 10.1080/21645515.2025.2611647. Epub 2026 Feb 2. ABSTRACT Parental vaccine hesitancy (VH) remains a significant public health challenge in France, despite mandatory childhood vaccination policies. Motivational interviewing (MI) has shown promise in reducing VH and increasing vaccination intentions. This study aimed to evaluate the sustained impact of an MI-based intervention on […]
Effects of an 8-Week App-Based Mindfulness Intervention on Mental Health in Working Women: Randomized Controlled Trial
J Med Internet Res. 2026 Feb 2;28:e62814. doi: 10.2196/62814. ABSTRACT BACKGROUND: Although working women experience increased work-related stress, preventive interventions to reduce its negative effects on their mental health are insufficient. OBJECTIVE: This study evaluated the effectiveness of an 8-week mindfulness-based self-help intervention via a smartphone app across 4 domains (general psychological, work-related, family-related, and […]
Optimization of a group-based intervention for people living with severe obesity (PROGROUP): Understanding fidelity to delivery and the patient experience
Br J Health Psychol. 2026 Feb;31(1):e70051. doi: 10.1111/bjhp.70051. ABSTRACT OBJECTIVES: Understanding the fidelity of delivery of complex health behaviour interventions is crucial in determining their effectiveness and identifying aspects needing refinement. PROGROUP is a group-based intervention for people with severe obesity. It aims to promote a shared social identity to support behaviour change. Data from […]